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Original papers

  • (57)
    Radical and Cation Crossover Reaction System Enables Synthesis of Complex Aliphatic Chains Possessing Functionalized Quaternary Carbons
    Y. Murata, T. Shimada, T. Nishikata*, Bull. Chem. Soc. Jpn., 2019, 92, 1419-1429.
  • (56)
    Construction of vicinal quaternary carbons via Cu-catalyzed dearomative radical addition
    N. Tsuchiya, T. Nishikata*, Chem. Lett., 2019, 48, 718-721.
  • (55)
    The Synthetic Protocol for <alpha>-Bromocarbonyl Compounds via Brominations
    Y. Murata, K. Takeuchi, T. Nishikata*, Tetrahedron, 2019, 75, 2726-2736.
  • (54)
    Iron-Enhanced Reactivity of Radicals Enables C–H Tertiary Alkylations for Construction of Functionalized Quaternary Carbons
    Y. Yamane, K. Yoshinaga, M. Sumimoto, T. Nishikata*, ACS Catal., 2019, 9, 1757-1762.
  • (53)
    Ppm Cu catalyst enables tert-alkylation followed by C-H cyclization to synthesize substituted oxindoles
    Y. Kohei, T. Naoya, Y. Murata, Y. Noda, T. Nishikata*, ACS Omega, 2018, 3, 9020-9026.
  • (52)
    Radical-Organometallic Hybrid Reaction System Enabling Couplings between Tertiary-Alkyl Groups and 1‑Alkenyl Groups
    K. Nakamura, R. Hara, Y. Sunada, T. Nishikata*, ACS Catal., 2018, 8, 6791-6795. (Cover Artに採択. プレスリリース, Most read articles)
  • (51)
    Facile Synthesis of Single α-tert-Alkylated Acetaldehydes via Hydroxyalkylation of Enamide in Water Solution
    Y. Murata, ,T. Nishikata*, Chem. Eur. J., 2018, 24, 6354.
  • (50)
    Copper-catalyzed functionalized tertiary-alkylative Sonogashira type couplings via copper acetylide at room temperature,
    Y. Yamane, N. Miwa, T. Nishikata*, ACS Catal., 2017,7, 6872-6876.
  • (49)
    Copper-catalyzed Amination of Congested and Functionalized α-Bromocarboxamides with Amines or Ammonia at Room Temperature,

    S. Ishida, K. Takeuchi, N. Taniyama, Y. Sunada, T. Nishikata*, Angew. Chem., Int. Ed., 2017, 56, 11610-11614
  • (48)
    Copper-catalyzed reductive borylations on water,

    C. Tanaka, K. Nakamura, T. Nishikata*, Tetrahedron, 2017, 73, 3999-4003.
  • (47)
    Amine-controlled Divergent Reaction: Iminolactonization and Olefination in the presence of a Cu(I) catalyst,
    T. Nishikata*, K. Itonaga, N. Yamaguchi, M. Sumimoto,
    Org. Lett., 2017, 19, 2686-2689
  • (46)
    Highly Efficient Cu Catalyst System for the Radical Reactions of α-Bromocarbonyls,
    Y. Noda, T. Nishikata*, Chem. Commun., 2017, 53, 5017-5019.
  • (45)
    Exchanging alkyl groups via unstrained C-C bond cleavage in the presence of a copper catalyst,
    M. Wada, Y. Noda, T. Nishikata*, Chem. Asian J., 2017, 12, 978-981.
  • (44)
    A ligand containing five nitrogen atoms enabled efficient homocyclization of alpha-bromocarbonyl amides in the presence of a copper catalyst, N. Miwa, Y. Yamane, T. Nishikata*,
    Chem. Lett., 2017, 46, 563-564.
  • (43)
    Dichloromethane as a Chlorination Reagent for α-Bromocarbonyl Compounds in the Presence of a Copper Catalyst,
    K. Takeuchi, S. Ishida, T. Nishikata*, Chem. Lett., 2017, 46, 644-645.
  • (42)
    Tandem reactions enable trans- and cis-hydro-tertiary-alkylations catalyzed by a copper salt,

    K. Nakamura, T. Nishikata*, ACS Catal., 2017, 7, 1049-1052. (Highlighted in Synfacts 2017,13, 496).
  • (41)
    Different behaviors of a Cu catalyst in amine solvents: Controlling N and O reactivities of amide,

    Y. Yamane, K. Miyazaki, T. Nishikata*, ACS Catal., 2016, 6, 7418-7425.
  • (40)
    Site-selective tertiary-alkyl–fluorine bond formation from alpha-bromoamides using a copper–CsF catalyst system,

    T. Nishikata*, S. Ishida, R. Fujimoto, Angew. Chem., Int. Ed., 2016, 55, 10008-10012.
  • (39)
    Powerful conditions for the direct arylations of furans at a sterically congested C-H bond,

    T. Nishikata*, Y. Yamane, Y. Yamaguchi, S. Ishikawa, Asian J. Org. Chem., 2016, 5, 466-469.
  • (38)
    Cationic Pd(II)-catalyzed C–H activation/cross-coupling reactions at toom temperature: synthetic and mechanistic studies
    ,
    T. Nishikata, A. R. Abela, S. Huang, B. H. Lipshutz, Beilstein J. Org. Chem, 2016, 12, 1040-1064.
  • (37)
    A Copper-Catalyzed Formal [3 + 2]-Cycloaddition for the Synthesis of All Different Aryl-Substituted Furans and Thiophenes,

    S. Ishikawa, Y. Noda, M. Wada, T. Nishikata*, J. Org. Chem., 2015, 80, 7555-7563. (Monthly Most Read Article)
  • (36)
    A Facile Formal [2+1] Cycloaddition of Styrenes with alpha-Bromocarbonyls catalyzed by Copper: An Efficient Synthesis of              Donor-Acceptor Cyclopropanes,
    T. Nishikata*, Y. Noda, R. Fujimoto, S. Ishikawa, Chem. Commun., 2015, 51, 12843-12846.
  • (35)
    A detachable ester bond enables perfect Z-alkylations of olefins for the synthesis of tri- and tetrasubstituted alkenes,

    T. Nishikata*, K. Nakamura, Y. Inoue, S. Ishikawa, Chem. Commun., 2015, 51, 10154-10157.
  • (34)
    Challenges in the substitution of terminal C-C double bonds with tertiary alkyl groups,

    T. Nishikata*, S. Ishikawa, Synlett, 2015, 716-724.(Synpacts: Invited)
  • (33)
    General and facile method for exo-methlyene synthesis via regioselective C-C double-bond formation using a copper-amine catalyst
    system, T. Nishikata*, K. Nakamura, K. Itonaga, S. Ishikawa, Org. Lett., 2014, 16, 5816-5819.
  • (32)
    Adhesive catalyst immobilization of palladium nanoparticles on cotton and filter paper: Applications to reusable catalysts for sequential catalytic reactions
    system, T. Nishikata, H. Tsutsumi, L. Gao, K. Kojima, K. Chikama, H. Nagashima, Adv. Synth. Catal., 2014, 356, 951-960.
  • (31)
    Catalysis on water: Hydrogenation of ketones and aldehydes by platinum nanoparticles dispersed in amphiphilic hyperbranched
    polystyrene, Pt@HPS-NR3 +Cl-,
    A. Chaiyanurakkul, L. Gao, T. Nishikata, K. Kojima, H. Nagashima, Chem. Lett., 2014, 43, 1233-1235.
  • (30)
    An Efficient Generation of a Functionalized Tertiary-Alkyl Radical for Copper-catalyzed Tertiary-Alkylative Mizoroki-Heck type Reaction,

    T. Nishikata*, Y. Noda, R. Fujimoto, T. Sakashita, J. Am. Chem. Soc., 2013, 135, 16372-16375.
    (Monthly Most Read Article, ファルマシア2014年2月号特集)
  • (29)
    Water- and Organo-Dispersible Gold Nanoparticles Supported by Using Ammonium Salts of Hyperbranched Polystyrene: Preparation and
    Catalysis,
    L. Gao, T. Nishikata, K. Kojima, K. Chikama, H. Nagashima, Chem. Asian J., 2013, 8, 3152-3163.
  • (28)
    Hydrophobicity/hydrophilicity tunable hyperbranched polystyrenes as novel supports for transition-metal nanoparticles
    ,
    K. Kojima, K. Chikama, M. Ishikawa, A. Tanaka, T. Nishikata, H. Tsutsumi, K. Igawa, H. Nagashima,
    Chem. Commun., 2012, 48, 10666-10668.
  • (27)
    N Alkylation of Tosylamides Using Esters as Primary and Tertiary Alkyl Sources: Mediated by Hydrosilanes Activated by a Ruthenium
    Catalyst,
    T. Nishikata, H. Nagashima, Angew. Chem., Int. Ed., 2012, 51, 5363-5366.
  • (26)
    Vinyl polymerization versus [1,3] O to C rearrangement in the ruthenium-catalyzed reactions of vinyl ethers with hydrosilanes,

    N. Harada, T. Nishikata, H. Nagashima, Tetrahedron, 2012, 68, 3243-3252.
  • (25)
    Hydrosilanes are not always a reducing reagent: a ruthenium-catalyzed introduction of primary alkyl groups to electron-rich aromatic rings
    using esters as a source of the alkyl groups,
    H. Nagashima, Y. Kubo, M. Kawamura, T. Nishikata, Y. Motoyama,
    Tetrahedron, 2011, 67, 7667-7672.
  • (24)
    TPGS-750-M: A Second-Generation Amphiphile for Metal-Catalyzed Cross-Couplings in Water at Room Temperature,

    B. H. Lipshutz, S. Ghorai, A. R. Abela, R. Moser, T. Nishikata, C. Duplais, A. Krasovskiy, R. D. Gaston, R. C. Gadwood,
    J. Org. Chem., 2011, 76, 4379-4391.
  • (23)
    A Chiral Bis(oxazoline) Ligand Embedded into Polysiloxane Gel: Application to a Reusable Copper Catalyst for Asymmetric
    Cyclopropanation, Y. Motoyama, T. Nishikata, H. Nagashima, Chem. Asian J., 2011, 6, 78-82.
  • (22)
    Cationic Pd(II)-Catalyzed Fujiwara-Moritani Reactions at Room Temperature in Water,

    T. Nishikata, B. H. Lipshutz, Org. Lett., 2010, 12, 1972-1975.
  • (21)
    Cationic Palladium(II) Catalysis: C-H Activation/Suzuki-Miyaura Couplings at Room Temperature,

    T. Nishikata, A. R. Abela, S. Huang, B. H. Lipshutz, J. Am. Chem. Soc., 2010, 132, 4978-4979.
  • (20)
    Room Temperature C-H Activation and Cross-Coupling of Aryl Ureas in Water,

    T. Nishikata, A. R. Abela, B. H. Lipshutz, Angew. Chem., Int. Ed., 2010, 49, 781-784.
  • (19)
    Pd-Catalyzed Synthesis of Allylic Silanes from Allylic Ethers
    ,
    R. Moser, T. Nishikata, B. H. Lipshutz, Org. Lett., 2010, 12, 28-31.
  • (18)
    Aminations of allylic phenyl ethers via micellar catalysis at room temperature in water,

    T. Nishikata, B. H. Lipshutz, Chem. Commun., 2009, 45, 6472-6474.
  • (17)
    Allylic Ethers as Educts for Suzuki-Miyaura Couplings in Water at Room Temperature,

    T. Nishikata, B. H. Lipshutz, J. Am. Chem. Soc., 2009, 131, 12103-12105.
  • (16)
    Amination of Allylic Alcohols in Water at Room Temperature,

    T. Nishikata, B. H. Lipshutz, Org. Lett., 2009, 11, 2377-2379.
  • (15)
    Asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated esters catalyzed by dicationic palladium(II)-chiraphos complex for
    short-step synthesis of SmithKline Beecham's endothelin receptor antagonist
    ,
    T. Nishikata, S. Kiyomura, Y. Yamamoto, N. Miyaura, Synlett, 2008, 2487-2490.
  • (14)
    Stepwise palladium-catalyzed 1,4-addition of arylboronic acids to enones and regioselective Baeyer-Villiger oxidation for enantioselective
    synthesis of β-diaryl esters and (+)-(R)-tolterodine, K. Kobayashi, T. Nishikata, Y. Yamamoto, N. Miyaura,

    Bull. Chem. Soc. Jpn
    ., 2008, 81, 1019-1025.
  • (13)
    Tandem conjugate addition-aldol cyclization to give optically active 1-aryl-1H-indenes via asymmetric Pd2+-catalyzed 1,4-addition of
    aryl-boronic acids,
    T. Nishikata, Y. Kobayashi, K. Kobayashi, Y. Yamamoto, N. Miyaura,Synlett, 2007, 3055-3057.
  • (12)
    Asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated N-acylamides catalyzed by dicationic palladium(II)-(S,S)-chiraphos
    complex,
    T. Nishikata, Y. Yamamoto, N. Miyaura, Chem. Lett., 2007, 36, 14421443.
  • (11)
    Palladium(II)-catalyzed 1,4-addition of arylboronic acids to β-arylenones for enantioselective synthesis of 4-aryl-4H-chromenes,

    T. Nishikata, Y. Yamamoto, N. Miyaura, Adv. Synth. Catal., 2007, 349, 1759-1764.
  • (10)
    Palladium(II)-catalyzed 1,4-addition of arylboronic acids to β-arylenals for enantioselective syntheses of 3,3-diarylalkanals: a short
    synthesis of (+)-(R)-CDP 840,
    T. Nishikata, Y. Yamamoto, N. Miyaura, Tetrahedron Lett., 2007, 48, 4007-4010.
  • (9)
    1,4-Addition of arylboronic acids to β-aryl-α,β-unsaturated ketones and esters catalyzed by a rhodium(I)-chiraphos complex for catalytic and enantioselective synthesis of selective endothelin A receptor antagonists
    ,
    T. Itoh, T. Mase, T. Nishikata, T. Iyama, H. Tachikawa, Y. Kobayashi, Y. Yamamoto, N. Miyaura, Tetrahedron, 2006, 62, 9610-9621.
  • (8)
    Enantioselective 1,4-Addition of Ar3Bi, [ArBF3]K, and ArSiF3 to Enones Catalyzed by a Dicationic Palladium(II)-Chiraphos or -Dipamp
    Complex,
    T. Nishikata, Y. Yamamoto, N. Miyaura, Organometallics, 2005, 24, 5025-5032.
  • (7)
    Asymmetric 1,4-addition of potassium aryltrifluoroborates [ArBF3]K to enones catalyzed by dicationic palladium(II) complexes
    ,
    T. Nishikata, Y. Yamamoto, N. Miyaura,
    Chem. Lett., 2005, 34, 720-721.
  • (6)
    Asymmetric 1,4-addition of triarylbismuths to enones catalyzed by dicationic palladium(II) complexes,   
    T. Nishikata, Y. Yamamoto, N. Miyaura,
    Chem. Commun., 2004, 1822-1823.
  • (5)
    1,4-Addition of Arylboronic Acids and Arylsiloxanes to α,β-Unsaturated Carbonyl Compounds via Transmetalation to Dicationic Palladium(II)
    Complexes,
    T. Nishikata, Y. Yamamoto, N. Miyaura, Organometallics, 2004, 23, 4317-4324.
  • (4)
    1,4-Addition of arylsiloxanes to enones catalyzed by dicationic palladium(II) complexes in aqueous media
    ,
    T. Nishikata, Y. Yamamoto, N. Miyaura, Chem. Lett., 2003, 32, 752-753.
  • (3)
    Conjugate addition of aryl boronic acids to enones catalyzed by cationic palladium(II)-phosphane complexes,  
    T. Nishikata, Y. Yamamoto, N. Miyaura,
    Angew. Chem., Int. Ed., 2003, 42, 2768-2770.
  • (2)
    Palladium-catalyzed novel addition-elimination reaction of alkenyltin reagents to norbornene,

    K. Fugami, Y. Hirunuma, T. Nishikata, D. Koyama, M. Kameyama, M. Kosugi, J. Organomet. Chem., 2003, 687, 567-569.
  • (1)
    Mizoroki-Heck Type Reaction of Organoboron Reagents with Alkenes and Alkynes. A Pd(II)-Catalyzed Pathway with Cu(OAc)2 as an Oxidant
    ,
    X. Du, M. Suguro, M. Hirabayashi, A. Mori, T. Nishikata, N. Hagiwara, K. Kawata, T. Okeda, H. F. Wang, K. Fugami, M. Kosugi,

    Org. Lett
    ., 2001, 3, 3313-3316.




Review

 
  • (9)
    Hybrid Reaction Systems for the Synthesis of Alkylated Compounds based upon Cu-catalyzed Coupling of Radicals and Organometallic Species,
    K. Takeuchi, Y. Murata, G. Hirata, T. D. Sheppard*, T. Nishikata*, Chem. Rec., 2019, accepted (invited).
  • (8)
    The Technology of Functionalized Tertiary-alkylations by Using the Reaction Field Near Copper Center,
    T. Nishikata*, J. Synth. Org. Chem., Jpn., 2019, 77, 120-134.(invited).
  • (7)
    Site selectivities in fluorination,
    S. Ishida, T. D. Sheppard*, T. Nishikata*, Tetrahedron Lett., 2018, 59, 789-798 (invited).
  • (6)
    Alkyl radicals controlled by Cu-amine catalyst system for the development of diverse reactions,

    T. Nishikata*, J. Synth. Org. Chem., Jpn., 74, 2 (2016).
  • (5)
    新反応をどのようにみつけるか?:銅-アミン触媒系が実現する第3アルキル基の新導入法

    西形 孝司、化学と工業、69, 592 (2016). (飛翔する若手研究者)
  • (4)
    遷移金属触媒を用いるヒドロシラン化学の新展開(II):ヒドロシランの機能は、還元剤だけではない。

    西形孝司、永島英夫、The Chemical Times, 14 (2012).
  • (3)
    Rhodium(I)- or palladium(II)-catalyzed 1,4-additions of organoboron, -silicon and -bismuth compounds to electron-deficient alkenes

    T. Nishikata, Y. Yamamoto, N. Miyaura, J. Synth. Org. Chem., Jpn., 64, 1112 (2006).
  • (2)
    1,4-additions of arylboron, -silicon, and -bismuth compounds to α,β-unsaturated carbonyl compounds catalyzed by dicationic palladium(II) complexes

    T. Nishikata, Y. Yamamoto, N. Miyaura, Pure Appl. Chem., 80, 807 (2008).
  • (1) Cationic Palladium(II) Catalysts for Conjugate Addition of Arylboron, -silicon, and –bismuth Compounds
      
    T. Nishikata, N. Miyaura, Syokubai, 47, 619 (2005).

Patents

  • (6)
    Electroless plating primer including hyperbranched polymer, metallic microparticles, and organic acid,

    H. Nagashima, T. Nishikata, K. Kojima, D. Saito, K. Odoi, K. Chikama, PCT Int. Appl. (2012), WO 2012141216 A1 20121018.
  • (5)
    Supported branched polymer-metal particulate complex catalysts and their manufacture,

    H. Nagashima, T. Nishikata, K. Kojima, A. Tanaka, S. Uesugi, Jpn. Kokai Tokkyo Koho (2012), JP 2012196666 A 20121018.
  • (4)
    Fluorinated hyperbranched polymer and process for production thereof,

    H. Nagashima, K. Igawa, T. Nishikata, K. Kojima, A. Tanaka, O. Uesugi, PCT Int. Appl. (2012), WO 2012074051 A1 20120607.
  • (3)
    One-step preparation of optically active substituted indenes,

    N. Miyaura, Y. Yamamoto, T. Nishikata, Jpn. Kokai Tokkyo Koho (2008), JP 2008214313 A  20080918.
  • (2)
    Preparation of optically-active β, β-diarylcarbonyl compounds and chromanol derivatives,

    N. Miyaura, Y. Yamamoto, T. Nishikata, Jpn. Kokai Tokkyo Koho (2008), JP 2008024607 A  20080207.
  • (1)
    Process for preparation of β-diaryl electron-withdrawing group substituted compounds,

    N. Miyaura, Y. Yamamoto, T. Nishikata, T. Itoh, PCT Int. Appl. (2008), WO 2008010455 A1 20080124.


Books

  • (2)
    Chapter 9. Iron-promoted reduction reactions,

    H. Nagashima, Y. Sunada, T. Nishikata, A. Chaiyanurakkul, The Chemistry of Organoiron Compounds, 2014, 325-328.
  • (1) 5章 シリコーンゲルを担体とする新しい固定化触媒
      
    永島英夫、西形孝司、CSJカレントレビュー11未来を拓く元素戦略―持続可能な社会を実現する化学, 2013, 56-61.


Articles

  • (4)
    ホウ素化合物の新しい修飾法-安定化することで見えてきた新しい合成化学
    西形孝司
    化学, 2018, 73, 72-73.
  • (3)
    飛翔する若手研究者 “新反応をどのようにみつけるか?:銅-アミン触媒系が実現する第三級アルキル基の新導入法”,

    西形孝司、化学と工業, 2016, vol 69-7, 592-593
  • (2)
    十字路 用語解説 “原子移動型ラジカル反応”,

    西形孝司、J. Synth. Org. Chem., Jpn, 2016, 74, 73.
  • (1)
    UCSB, Lipshutz研での研究と留学生活

    西形孝司、Organometallic News, 2012, (1), 18-19.